I'd be happy to help. We have not personally tested it on many variations of Mac systems, however, we have successfully ran it for the last several weeks on one iMac we have in the office with High Sierra with no problems at all. This iMac is a 27 inch model from around 2015 with an Nvidia Geforce graphics card. We have not heard any negative reports from customers using it with AMD Radeon, etc. Of course Intel Iris or Intel HD graphics are not supported regardless. I would say with my personal experience with High Sierra that there are some weird graphics rendering issues actually NOT involved in Mediashout. For instance I'm not sure if the Nvidia Geforce Web Driver is currently compatible, and I've seen even my Google Chrome and other apps have white or black screens over them momentarily until closing and reopening etc. I'm not sure if that issue is unique to the Mac I put it on or not. But all that to say-- there may be some kinks you'll see on the OS itself, but as far as I've been able to see, Mediashout has been fine. Hope this helps!