Hey Bob, I'm sorry about the trouble here. It sounds like some things are just out of whack. There's not an issue in MediaShout that will cause this to happen. It's likely a culmination of all the system changes and adjustments made to the configuration in attempt to make it work before, and now some issues with the configuration on the new video card. We don't have refunds, but we're here to make it work for you.
Here are the steps to clear the MediaShout registry key just to make sure we're talking about the same thing:
1) Close MediaShout
2) Go to the start menu search bar and type "regedit" with no quotes and press enter
3) Go to HKEY CURRENT USER then Software then MediaComplete
4) See the MediaShout 6 folder/key and right click it to delete it
5) Try starting MediaShout again
It will recreate this key everytime you launch the program, it has to, to be able to run.
Deleting that key will affect any already saved routing that MediaShout will have to send out to the monitors, but will NOT fix a problem with MediaShout not seeing those monitors if they don't show up.
That would usually be a hardware or connection/configuration issue. Maybe even a driver issue with the video card or monitors in Windows.
If you go to dxdiag and click on the Display1 and Display 2, (and Display 3 if you have it), and look on the "Monitor: " line-- does it show at least something like "Generic PnP Monitor" or does it show an "X" there? If it shows an X it means there's still a system issue that needs to be taken care of.
In either case, we sometimes see invalid monitor drivers loaded. If you look in Device Manager, go down to the Monitors section, and make sure each monitor number 1 doesn't have any issues listed, or little notification badges on the icons, and that they are all using correct drivers, like generic Microsoft drivers, or Dell drivers for a Dell monitor, etc. If using something odd like a Teamviewer driver or something like that, they should be rolled back to standard and that may fix it.
If that doesn't resolve it, let us know and we can troubleshoot further, we are here for you. If you are within 30 days of the purchase, you can just call the support line and we can help via remote session even, to check things out (it may not be a MediaShout issue, but we can check a couple things and advise what to do to move forward, and we'll try to go the extra mile in this scenario). Or if you're past 30 days, maybe do a live chat with us for free on the support page, or consider getting just 1 month of the Plus Membership for $17, which includes a media pack worth much more than that, and it will give you a 30 day window for us to remote in and help as needed.