Anytime you are using a Switcher to switch between using MediaShout and something else, the opportunity for the connection to drop is large. To mitigate this, you may want to look into purchasing an EDID Emulator (http://connectpro.com/video-solutions/ddc-emulators/). This will keep the connection between the computer and that switcher constant (so, the computer and MediaShout never lose the connection with the screens).
I hope this is helpful!
Thanks and God Bless,